Biochemistry: A Short Course

John L. Tymoczko is Towsley Professor of Biology at Carleton College, where he has taught since 1976. He currently teaches Biochemistry, the Metabolic Basis of Human Disease, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry and co-teaches an introductory course, Energy Flow in Biological Systems. Jeremy M. Berg received his B.S. and M.S. degrees in Chemistry from Stanford (where he did research with Keith Hodgson and Lubert Stryer) and his Ph.D. in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine. Gregory Gatto Jr., GlaxoSmithKline Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his M.D. from Harvard Medical School."

PART I The Molecular Design of Life.- SECTION 1 Biochemistry Helps Us Understand Our World.- 1. Biochemistry and the Unity of Life.- 2. Water, Weak Bonds, and the Generation of Order Out of Chaos.- SECTION 2 Protein Composition and Structure.- 3. Amino Acids.- 4. Protein Three-Dimensional Structure.- 5. Techniques in Protein Biochemistry.- SECTION 3 Basic Concepts and Kinetics of Enzymes.- 6. Basic Concepts of Enzyme Action.- 7. Kinetics and Regulation.- 8. Mechanisms and Inhibitors.- 9. Hemoglobin, an Allosteric Protein.- SECTION 4 Carbohydrates and Lipids.- 10. Carbohydrates.- 11. Lipids SECTION 5 Cell Membranes, Channels, Pumps, and Receptors.- 12. Membrane Structure and Function.- 13. Signal-Transduction Pathways.- PART II Transducing and Storing Energy.- SECTION 6 Basic Concepts and Design of Metabolism.- 14. Digestion: Turning a Meal into Cellular Biochemicals.- 15. Metabolism: Basic Concepts and Design.- SECTION 7 Glycolysis and Gluconeogenesis.- 16. Glycolysis.- 17. Gluconeogenesis.- SECTION 8 The Citric Acid Cycle.- 18. Preparation for the Cycle.- 19. Harvesting Electrons from the Cycle.- SECTION 9 Oxidative Phosphorylation.- 20. The Electron-Transport Chain.- 21. The Proton-Motive Force.- SECTION 10 The Light Reactions of Photosynthesis and the Calvin Cycle.- 22. The Light Reactions.- 23. The Calvin Cycle.- SECTION 11 Glycogen Metabolism and the Pentose Phosphate Pathway.- 24. Glycogen Degradation.- 25. Glycogen Synthesis.- 26.The Pentose Phosphate Pathway.- SECTION 12 Fatty Acid and Lipid Metabolism.- 27. Fatty Acid Degradation.- 28. Fatty Acid Synthesis.- 29. Lipid Synthesis: Storage Lipids, Phospholipids, and Cholesterol.- SECTION 13 The Metabolism of Nitrogen-Containing Molecules.- 30. Amino Acid Degradation and the Urea Cycle.- 31. Amino Acid Synthesis.- 32. Nucleotide Metabolism.- PART III Synthesizing the Molecules of Life.- SECTION 14 Nucleic Acid Structure and DNA Replication.- 33. The Structure of Informational Macromolecules: DNA and RNA.- 34. DNA Replication.- 35. DNA Repair and Recombination.- SECTION 15 RNA Synthesis, Processing, and Regulation.- 36. RNA Synthesis and Regulation in Bacteria.- 37. Gene Expression in Eukaryotes.- 38. RNA Processing in Eukaryotes.- SECTION 16 Protein Synthesis and Recombinant DNA Techniques.- 39. The Genetic Code. 40. The Mechanism of Protein Synthesis.- 41. Recombinant DNA Techniques.