Textbook of Diabetes

" The undersigned immediately liked that each chapter begins with a summary in the form of key points on a colored background. It makes it possible to foam the text fairly quickly by reading the summary only. Tables and figures also have the same background, making the book clear and easy to read" (direct translation) Journal of the Norwegian Medical Association, Sept 2017

Richard I.G. Holt, MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK. Clive S. Cockram, MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. Allan Flyvbjerg, MD, DMSc Professor of Clinical Endocrinology and Chair, Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital - Aarhus University, Aarhus, Denmark. Barry J. Goldstein, MD, PhD, FACP, FACE Therapeutic Area Head, Diabetes and Obesity, Vice President, Clinical Research, Metabolism, Merck Research Laboratories, Rahway, NJ, USA.

List of Contributors viii Preface to the Fifth Edition xiv List of Abbreviations xv About the Companion Website and Companion Digital Edition xviii Part 1 Diabetes in its Historical and Social Context 1 The History of Diabetes Mellitus 3 Robert B. Tattersall 2 Classification and Diagnosis of Diabetes 23 Ambady Ramachandran, Chamukuttan Snehalatha, and Arun Nanditha 3 Epidemiology of Type 1 Diabetes 29 Lars C. Stene and Jaakko Tuomilehto 4 Epidemiology of Type 2 Diabetes 43 Ronald C.W. Ma and Peter C.Y. Tong 5 The Global Burden of Diabetes 65 Mohammed K. Ali, Karla I. Galaviz, Mary Beth Weber, and K.M. Venkat Narayan Part 2 Normal Physiology 6 Islet Function and Insulin Secretion 87 Peter M. Jones and Shanta J. Persaud 7 Glucagon in Islet and Metabolic Regulation 103 Darleen Sandoval, Jenny Tong, and David D Alessio 8 Mechanism of Insulin Action 114 Morris F. White 9 Control of Weight: How Do We Get Fat? 133 Arianne N. Sweeting and Ian D. Caterson Part 3 Pathogenesis of Diabetes 10 Autoimmune Type 1 Diabetes 143 Shehab Alshiekh, Helena Elding Larsson, Sten-A. Ivarsson, and ke Lernmark 11 Other Disorders with Type 1 Phenotype 154 Alice P.S. Kong, Elaine Y.K. Chow, and Juliana C.N. Chan 12 Abnormalities of Insulin Secretion and -Cell Defects in Type 2 Diabetes 161 Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele 13 Insulin Resistance in Type 2 Diabetes 174 Michael Roden, Kitt Petersen, and Gerald Shulman 14 Genetic Architecture of Type 2 Diabetes 187 Rashmi B. Prasad and Leif Groop 15 Metabolic Disturbances in Diabetes 205 Adrian Vella and Robert A. Rizza 16 Obesity and Diabetes 215 Hans Hauner 17 The Microbiome and Diabetes 229 Amanda J. Cox, Nicholas P. West, and AllanW. Cripps Part 4 Other Types of Diabetes 18 Monogenic Causes of Diabetes 243 Shivani Misra and Andrew T. Hattersley 19 Drug-Induced Diabetes 262 Charles D. Ponte and Devra K. Dang 20 Endocrine Disorders that Cause Diabetes 272 Rachel E. Jennings and Neil A. Hanley 21 Pancreatic Diseases and Diabetes 291 Ranjit Unnikrishnan and Viswanathan Mohan Part 5 Managing the Patient with Diabetes 22 Clinical Presentations of Diabetes 305 Ee Lin Lim and Roy Taylor 23 The Aims of Diabetes Care 314 Katharine D. Barnard and Richard I.G. Holt 24 Educating the Person with Diabetes 326 Ingrid Willaing and Michael Vallis 25 Lifestyle Issues: Diet 341 Nicola Guess 26 Lifestyle Issues: Exercise 353 Mimi Z. Chen and Robert C. Andrews 27 Monitoring Diabetes 374 Andrew Farmer 28 Drug Therapy: Special Considerations in Diabetes 385 Bernard M.Y. Cheung and Ronald C.W. Ma Part 6 Treatment of Diabetes 29 Insulin and Insulin Treatment 401 Stephen Gough and Parth Narendran 30 New Technologies for Glucose Monitoring and Insulin Administration 414 David L. Horwitz and David C. Klonoff 31 Oral Glucose-Lowering Agents 426 Clifford J. Bailey and Andrew J. Krentz 32 Non-Insulin Parenteral Therapie 455 Tina Vilsbll, Mikkel Christensen, Tina Jorsal, and Filip K. Knop 33 How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies 471 Silvio E. Inzucchi and David R. Matthews 34 In-Hospital Treatment and Surgery in People with Diabetes 493 Ketan Dhatariya and June James 35 Hypoglycemia in Diabetes 513 Philip E. Cryer and Ana Mara Arbelez 36 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State 534 Niels Mller Part 7 Microvascular Complications in Diabetes 37 Pathogenesis of Microvascular Complications 543 Allan Flyvbjerg 38 Diabetic Retinopathy 554 Toke Bek 39 Diabetic Nephropathy 566 Sally M. Marshall and Allan Flyvbjerg 40 Diabetic Peripheral and Autonomic Neuropath 580 Dan Ziegler Part 8 Macrovascular Complications in Diabetes 41 Pathogenesis of Macrovascular Complications in Diabetes 611 Stephen P. Gray, Elyse Di Marco, Riccardo Candido, Mark E. Cooper, and Karin A.M. Jandeleit-Dahm 42 Cardiovascular